منابع مشابه
Modulation of Ion Channels: Minireview A “Current” View of AKAPs
Vollum Institute sites on AKAPs have been used to establish a role for Oregon Health Sciences University these proteins in functional coupling to a variety of ion Portland, Oregon 97201 channels. Many of these studies were made possible by the development of an anchoring inhibitor peptide derived from the RII binding site of an AKAP (Ht31), Deciphering the molecular organization of synapses and...
متن کاملModulation of Ion Channels A “Current” View of AKAPs
Vollum Institute sites on AKAPs have been used to establish a role for Oregon Health Sciences University these proteins in functional coupling to a variety of ion Portland, Oregon 97201 channels. Many of these studies were made possible by the development of an anchoring inhibitor peptide derived from the RII binding site of an AKAP (Ht31), Deciphering the molecular organization of synapses and...
متن کاملAllosteric modulation of ligand gated ion channels by ivermectin.
Ivermectin acts as a positive allosteric regulator of several ligand-gated channels including the glutamate-gated chloride channel (GluCl), gamma aminobutyric acid type-A receptor, glycine receptor, neuronal alpha7-nicotinic receptor and purinergic P2X4 receptor. In most of the ivermectin-sensitive channels, the effects of ivermectin include the potentiation of agonist-induced currents at low c...
متن کاملModulation of transmitter release via presynaptic ligand-gated ion channels.
Neurons communicate through the exocytotic release of transmitters from presynaptic axon terminals and the ensuing activation of postsynaptic receptors. Instantaneous responses of postsynaptic cells to released neurotransmitters are mediated by ligand-gated ion channels, whereas G protein-coupled receptors mediate rather delayed effects. Moreover, the actions of ionotropic receptors are transie...
متن کاملO 13: Ion Channels in Autoimmune Neurodegeneration
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
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ژورنال
عنوان ژورنال: Neuron
سال: 1999
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80795-3